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Title   면역기능 감소 환자에서 발생한 Typhlitis 4예 ( Four Cases of Typhlitis, Developed in Neutropenic State and Treated with Medical Conservative Management )
Publicationinfo   1997 Jan; 029(05): 906-914.
Key_word   Typhlitis, Neutropenia, Antibiotics, Chemotherapy
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Abstract   Typhlitis is a life threatening necrotizing enterocolitis of the cecum, ascending colon and terminal ileum seen in severely neutropenic patients, however its pathogenesis is not identified up to this time. The incidence of typhlitis in leukemic patient is 10-12%, estimated by postmortem examination, and 46% in induction chemotherapy of leukemia. Recently, entity incidence is more high due to increasing challenges to high dose chemotherapy in solid tumors. We experienced four cases of typhlitis, one was developed in the circumstance of neutropenia induced by induction chemotherapy for acute myelocytic leukemia and others in neutropnia due to primary diseases without chemotherapy, ig, chronic myelocytic leukemia, acute lymphocytic leukemia, myelodysplastic syndrome. All cases were treated with high dose broad spectrum antibiotics in early phase of disease and its outcome was good, so that, early diagnosis of typhlitis is essential, then prompt treatment with high dose antibiotics and intravenous fluid before onset of transmural necrosis is associated with lower morbidity and mortality than surgical resection.
저 자   김필운(Pil Woon Kim),지현규(Hyung Kyu Ji),정현식(Hyun Sik Jeong),문찬일(Chan Il Moon),양동경(Dong Kyung Yang),이승원(Seung Won Lee),정연실(Yeon Sil Chung),최지호(JI Ho Choi)남귀현(Kwi Hyun Nam),이재훈(Jae Hoon Lee),신동복(Dong Bok Shin),